In both models, the peritoneal wall was the critical border for systemic infection. These results show the dual role of the sympathetic nervous system in sepsis. It can be favorable or unfavorable, depending on the innate immune effector mechanisms necessary to overcome infection
There is now agreement that sepsis and the systemic inflammatory response syndrome are accompanied by a dysregulation of the inflammatory response. During the onset of sepsis, the inflammatory system becomes hyperactive, evoking a strong anti-inflammatory feedback response by the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS).
http://jid.oxfordjournals.org/content/192/4/560.full
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